PKVisualization

BIOMEDICAL ILLUSTRATION & ANIMATION


Research in Mild Traumatic Brain Injuries (mTBIs)


Project Description
  • » Research poster


  • Athletes engaged in high-impact sports are at high risk of incurring a type of brain injury known as concussion. To communicate the mechanisms underlying sports-related concussions, we have created a high-end 3D animation in Autodesk Maya, focusing on the biomechanics and pathophysiology of the condition.


    Background

    In collegiate sports, mild traumatic brain injuries (mTBIs) may constitute the most common form of injury. Many retired professional athletes in high-impact sports such as hockey and football have gone public about their health problems suspected to be connected with concussions that took place during their careers. Providing visual evidence of the rationale behind return-to-play guidelines may help to increase adherence and awareness.


    References

    For a comprehensive list of of all references used in this project, CLICK HERE. This bibliography includes sources in the areas of concussion assessment, clinical outcomes, biomechanics of injury, and pathophysiology. I have also included references for visual strategies to enhance learning.


    Project Committee

    Nicholas Woolridge, BFA, BScBMC, MScBMC, MSc, CMI

    Director & Associate Professor, Biomedical Communications

    Department of Biology

    University of Toronto Mississauga


    Doug Richards, MD, DipSportMed

    Assistant Professor, Faculty of Physical Education and Health

    Medical Director, David L. MacIntosh Sport Medicine Clinic

    University of Toronto


    Anne Agur, BScOT, MSc, PhD

    Professor, Institute of Medical Science (IMS)

    Department of Surgery, Division of Anatomy

    Graduate Department Rehabilitation Sciences (GDRS)

    University of Toronto







    Objectives

    1. Communicate a compelling interpretation of the physical response of brain tissue to high acceleration and deceleration forces.

    2. Depict the currently proposed mechanism of diffuse axonal injuries as a cellular-level component of injury.

    3. Communicate microtubule breakage in axons.

    Discussion

    An evidence-based visualization depicting deformation of human brain tissue and axonal injuries possibly connected with mTBIs can assist both players and coaches in understanding the importance of preventative strategies, proper injury management and strict adherance to return-to-play guidelines. This visualization could also potentially be of use to bioengineers and sports medicine professionals conducting research into the epidemiology of mTBI.


    The research surrounding traumatic head injuries is rich for opportunities to visualize. Some potential future visualizaions may include:

    • Short- and long-term clinical manifestations

    • Consequences of cumulative sub-concussive hits

    • Indirect impacts that transfer rotational acceleration

    • Role of tau and beta-amyloid proteins

    • Related biochemical pathways

    • Associated mitochondrial dysfunction


    This animation was completed over the course of a year and involved well over 600 hours of production time.


    Acknowledgements

    This project would not be possible were it not for the expertise and patience of my professors at BMC, especially Marc Dryer & Michael Corrin.


    Special thanks to the presenters at the 6th Annual Injury Biomechanics Symposium in Columbus, Ohio USA.


    Invaluable assistance was provided by neurosurgeons at St. Michael's Hospital, Toronto, ON Canada.


    Process